Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue
نویسندگان
چکیده
منابع مشابه
Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue
The mechanism by which CD4 T cells are depleted in HIV-infected hosts remains poorly understood. In ex vivo cultures of human tonsil tissue, CD4 T cells undergo a pronounced cytopathic response following HIV infection. Strikingly, >95% of these dying cells are not productively infected but instead correspond to bystander cells. We now show that the death of these "bystander" cells involves abor...
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T he hallmark of HIV infection is the depletion of CD4 + T cells in peripheral blood, lymphoid organs, and mucosal tissues [1]. Since CD4 + T cells play an essential role in immune defenses against almost all pathogens, HIV-positive patients are subject to a variety of opportunistic infections. Despite decades of intensive research, the mechanisms underlying CD4 + T cell depletion remain widely...
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ژورنال
عنوان ژورنال: Cell
سال: 2010
ISSN: 0092-8674
DOI: 10.1016/j.cell.2010.11.001